In our introduction to this Debates & Developments forum, ‘What place for the Region?’, we discuss why the founders of the International Journal of Urban and Regional Research (IJURR) regarded the regional question as having the same importance as the urban question, and how the region has remained a significant focus during the journal’s subsequent development. We then explore some of the conceptual challenges in defining and investigating regions before considering some of the key developments in contemporary regional theory. Our introduction proceeds by highlighting the key insights of the contributions to the forum––essays by Edward Soja, Mariona Tomàs, Joe Beall, Susan Parnell and Chris Albertyn, and Jean-Paul Addie and Roger Keil––before concluding with a reaffirmation of the importance of the region in IJURR’s mission as a journal of critical urban and regional studies.